Erm, if you go a Dexazon fallens in normal can kill you. You can easily get good damage with charms, I'd say. Sacrificing that much Vitality will be the end of that Zon, thats for sure. I have a Bowazon, 345 Dex and 212 Vit, lvl 87. She has 1347 HP with charms, It's nice.

DR will reduce damage but not enough to save your life I think.