Spirit isn't duped. You could make it yourself easily.
Now the rest, are probably duped. If you consider how much stronger the monsters are now, the runewords do help in defeating them, but aren't necessary. I approach that with a character that has some uniques/sets and then a runeword or two,m so the game isn't stupidly easy but nor super duper hard either. It's at middle level that's fun and challenging for me.
